A 70' Hatteras M/Y will make the trip from Corpus Christi to San Diego. The Key is preparation and crew. Like a few have said before, pick your days, pick your team, have plenty of fuel, cash and parts. It would be a fun trip with lots of stories. Financially it may be better to ship her over, and you can do that out of Houston. I checked on it for something I was working on. Great idea to ask, and do some homework, but it can be done. I would do it. I hope to do it in 10 years from now, so document everything please!
Also Remember, the Santa Maria was Columbus' largest boat at 54' overall and an 18' beam! he didn't have charts, GPS, radios, or refrigeration...