Yep - Mobile to Alabama depends on your mood - you can run in the Ditch to Appalachicola or you can go outside and duck in for fuel as required.
From Appalachicola to Tampa is a nice run, just look at the WX before you go. There's fuel in Appalachicola. You CAN hug the coast and go into Steinhatchee, but I wouldn't - cut it off and go direct at that point.
Beware the Destin Pass - if you're coming in here I have very SPECIFIC instructions for you that, if not followed, are likely to lead to you grounding your boat during the transit of the inlet! No, the channel markers are NOT to be trusted when you have a 5'+ draft.
If you have the legs you could run either Destin or even Mobile direct to Tampa, but you're not doing that on plane in these boats. Destin direct is possible at displacement speeds (~0.9nmpg) though, and is to be considered if you have the crew (3 qualified watch-standers) as it will be materially cheaper in fuel and get you there in just as many calendar days as doing it the other way but at higher speeds.