Pat, based on the limited amount I know I would not shy away from self-contained units- the big disadvantage is that you are running seawater all over the boat to supply them. This means a bigger seawater pump and all that plumbing. The advantage is that the units are precharged etc and you don't have to pull new copper tubing through the boat.
Another thing to consider is that they add weight rather high up in the boat, because all the hardware is now up in the passenger spaces. Modern systems are lighter than older ones. They are quieter, however a sefl-contained unit which contains a compressor AND airhandler will probably be a little louder than the topside part of the old split system that had only the airhandler up above.
I was told on good authority that Marine Air Systems units are very good, but that the ones they sell through retailers such as WM and BUS are not as good as the self-contained ones that their dealers get. The warranty is also not as good, which tells you something. My HVAC friends tell me that scroll compressors are the best around- quiet, efficient, and durable. They rave about them. How long they've been around I don't know.
One of the things I DON'T like about my current AC installation, which is factory from Hatteras, is that the Vberth unit is mounted high up in the anchor locker where it puts weight in front up high, exposes the unit to sea air vapor, and results in more noise in the Vberth. It would have been far better down under the bunks and ducted up to the Vberth area. The compressor for it, of course, is in the engine room, which is good- the heaviest part is down low in the boat. If I have to replace it, I will probably put a split system in again but move the airhandler down lower in the boat under the bunks, and duct it. You may have a similar setup from new in your 50C.
Let us know what you decide to do...I am interested to hear about it.