3160s, which were the direct ancestor of the 3208, are low-power, low-stress natural versions of that engine. They will run a very long time indeed. There are quite a few 36Cs from the early seventies which are running around with those engines in them; some of their owners are forum members.
The top of the curve on 3208 reliability, I was told by CAT techs who have rebuilt many of them, is the 355 hp version. After that, the ratio of juice to squeeze gets less favorable, and they don't last nearly as long. The 3160s were rated at 180hp, the 3208Ns at 210, and then up from there. In a 36C, I think you can get up to the 325 or 355 hp version before the engine gets so tall that the hatches won't close.
Incidentally, there is a piece of conventional wisdom that states that parent-bore engines like the 3208 cannot be rebuilt. I don't think this is true, though-they can be bored and honed within reason just like any other parent-bore (non-sleeved) engine, as far as I know. 3208s have for years been one of the more popular engines for Chesapeake Bay watermens' boats, who beat the daylights out of their vessels.