I don't think there's any difference, practically speaking, between the life of 8-71s and 6-71s, both naturals. Either engine will last a very long time if properly maintained; they ae pretty low-stress units. Yes, they are noisy, and they leak oil, and are not especially economical, but for what it would cost to replace them you can buy a lot of diesel fuel. The noise you can learn to live with, the oil leaking can be at least partly resolved by paying attention to the various drains and rerouting crankcase pressure using CCVs instead of AirSeps.
The 43 MY will be faster; they weigh less and the power/weight ratio is better. If you don't mind going slow, on a 53 with N series Detroits you'll be able to go slow for a long time. I think the 53s with 92 series engines were able to go somewhat faster, but none of these boats are speedy and if you want to get places fast you should get a different boat. Even cramming bigger engines in (totally impractical) wouldn't really get you much of a performance dividend. You'd pay dearly for your knots. In fuel and upkeep, if you ask me.
53MYs offer nice interior accommodations, a classic look, good build quality, a good ride and weather capabilities. I think they are a narrow boat by modern standards and this and the decor are probably what date them more than anything else, according to my broker friends. They are complex boats with a lot of ships' systems and, compared to boats built now, probably too many electrical systems, but at the time they were made, they were very much up to date and they were strongly put together. If you can find a nice one which has had its maintenance and upgrades, is solid and looks the way you want, there is no reason not to buy it. Live within its capabilities and you'll be a very happy boater for a long time.