Anybody ever navigated the uncharted parts?

Looking at delivering a boat for a guy who bought a boat on Lake Cumberland (landlocked), and it's going to have to be trucked from the lake to a ramp below the dam on the river. This is one of those spur of the moment type moves, so I'm hoping I can find somebody who has run the thing. I've run it from around Hendersonville/Gallatin on to the Ohio, but never that particular stretch which is indeed devoid of nav markers. Just a pretty shade of blue on the ole' Navionics and where the paper charts end/begin. With that, I'm looking at some 80 miles of reading the river , which is probably muddier than dammitt right now.